Targeted retroviral infection of tumor cells by receptor cooperation.
نویسندگان
چکیده
Retroviruses expressing two different receptor-binding domains linked by proline-rich spacers infect only cells expressing both retroviral receptors (Valsesia-Wittman et al., EMBO J. 6:1214-1223, 1997). Here we apply this receptor cooperation strategy to target human tumor cells by linking single-chain antibodies recognizing tumor antigens via proline-rich spacers to the 4070A murine leukemia virus surface protein.
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ورودعنوان ژورنال:
- Journal of virology
دوره 77 4 شماره
صفحات -
تاریخ انتشار 2003